Dr. Jaroslaw Harezlak was awarded a 5-year R01 grant from NIMH to develop “Statistical Models for Multi-Modal Brain Imaging Studies”. Statistical method development proposed in his grant is driven by the study of neurocognitive impairment and its progression in HIV patients which include multi-modal brain imaging measures, as well as, longitudinal host and viral markers. The project will focus on determining imaging markers discriminating between HIV-infected patients and matched HIV-negative controls and establishing specific biomarkers of NCI diagnosis and progression among HIV-infected individuals. Statistical methods developed will be widely applicable to a range of neurodegenerative conditions, including dementia and Alzheimer’s disease.
Dr. Harezlak’s work will be conducted with collaborators at the Washington University in St. Louis (Dr. Ances), Fred Hutchinson Cancer Research Center (Dr. Randolph) and his study team in Indiana will include Dr Yiannoutsos (IU RMFSPH), Dr Goni (Purdue Univ.) and a postdoctoral fellow.