Barry P. Katz
The State University of New York, Binghamton, NY, B.A. (Mathematics), 1977
The University of Michigan, Ann Arbor, MI, M.P.H. (Biostatistics), 1979
The University of Michigan, Ann Arbor, MI, Ph.D. (Biostatistics), 1984
1984 – 1989 Assistant Professor, Department of Medicine, Indiana University, Indianapolis, IN
1989 – 1996 Associate Professor, Department of Medicine, Indiana University, Indianapolis, IN
1995 – 2011 Director, Division of Biostatistics, Department of Medicine, Indiana University, Indianapolis, IN
1996 – 2011 Professor, Department of Medicine, Indiana University, Indianapolis, IN
2011 - Professor, Department of Biostatistics, Indiana University School of Medicine, Indianapolis, IN
Department of Preventive and Community Dentistry, Indiana University School of Dentistry.
Department of Public Health, Indiana University School of Medicine.
Department of Mathematics, Purdue University School of Science
Selected Awards and National Service:
1994–98 AHCPR Health Care Technology and Decision Sciences Study Section,
1996 Centers for Disease Control - Expert Panel for updating guidelines for laboratory based diagnosis of chlamydial and gonococcal infections.
1997 Advisor to the Allocation Subcommittee of Attorneys General in the development of the formula used to divide tobacco settlement proceeds among the states.
2000 Recognition award from the American Statistical Association for outstanding service to the Central Indiana Chapter
2001- 05 NIH Hyper-ID Scientific Review Group
2008 - Board of Directors, Datalys Center for Sports Injury Research and Prevention
2010 American Dental Association/Centers for Disease Control – Expert Panel on Non-Fluoride Caries Preventative Agents
Since 1984 when I arrived at Indiana University, I have been involved in a wide variety of health research projects. My longest term collaboration is focused on sexually transmitted diseases (STD). I served as the director of the Biostatistics Core for a series of STD Research Centers and participated in a wide variety of epidemiologic, behavioral and randomized studies. One of the centers focused on a cohort of adolescent women that was followed for more than seven years and resulted in large number of publications describing the sexual behavior and disease risk of young women as they progress to young adulthood (e.g. Katz et. al. Sexually Transmitted Diseases, 2001). A second area of research has been joint disease, including the study of pharmacologic, educational, and surgical interventions for osteoarthritis (OA). I directed the coordinating center for the first, and only successful, multicenter trial of a disease modifying drug for OA (Brandt et. al, Arthritis and Rheumatism, 2005). I have also had a research interest in the evaluation of new diagnostic and treatment methods for early dental caries, with particular emphasis on new imaging techniques. Two ongoing studies focus on the prediction of caries in school age children in Puerto Rico and very young children in three US sites. Currently, I am leading the statistical efforts for the multi-institutional Medical Countermeasures Against Radiological Threats (MCART) consortium which developed animal models to evaluate pharmacologic interventions to treat radiation exposure.
My methodologic research has been based on my collaborative projects. In this way, statistical developments have direct application to real problems. This strategy has led to research in a variety of biostatistical areas. For example, based on data routinely collected as part of a sexually transmitted diseases (STD) control program, I used a deterministic model to estimate the transmission rate for chlamydial infection (Katz, Statistics in Medicine, 1992). Recently, Wanzhu Tu and I developed a stochastic model for estimating transmission using longitudinal data (Tu, et. al., Journal of the Royal Statistical Society A, 2011). Similarly, I developed (in collaboration with former faculty member Andrew Zhou) a model of small area variation in knee replacement surgery by combining extra-Poisson regression models with empirical Bayes techniques (Zhou et. al. Statistics in Medicine, 1996). In the area of caries research, my projects related to new diagnostic methods for early caries, Ied me to propose multiple methods for combining measures of caries incidence to improve power in randomized caries trials (Katz and Huntington, Journal of Dental Research, 2004).
Recent Publications (In chronological order; selected from 214 peer reviewed publications):
1. Roth AM, Ackermann RT, Downs SM, Downs AM, Zillich AJ, Holmes AM, Katz BP, Murray MD, Inui TS. The structure and content of telephonic scripts found useful in a Medicaid chronic disease management program. Chronic Illness. 2010; 6:83-8.
2. Ott M, Ofner S, Tu W, Katz BP, Fortenberry JD. Influences on sex after periods of abstinence among sexually experienced young women. Perspectives on Sexual and Reproductive Health. 2010; 42:43-48.
3. Batteiger BE, Tu W, Ofner S, Van Der Pol B, Stothard DR, Orr DP, Katz BP, Fortenberry JD. Repeated Chlamydia trachomtis infections in adolescent women. Journal of Infectious Diseases. 2010; 201:42-51.
4. Fife KH, Williams JA, Thomas AL, Ofner S, Katz BP, Fortenberry JD. Herpes simplex virus type 2 infection in young adult women: Risk factors for acquisition and frequency of viral shedding. Sex Trans Diseases. In press.
5. Li W, Tenner-Racz K, Racz P, Janowicz DM, Fortney KR, Katz BP, Spinola SM. Role played by CD4+FOXP3+ regulatory T cells in failure to clear Haemophilus ducreyi during experimental infection of human volunteers. Journal of Infectious Diseases. 2010; 201:1839-48.
6. Mount KLB, Townsend CA, Rinker SD, Gu X, Fortney KR, Zwickl BW, Janowiscz DM, Spinola SM, Katz BP, Bauer ME. Haemophilus ducreyi SapA contributes to cathelicidin resistance and virulence in humans. Infection and Immunity. 2010; 78:1176-84.
7. Spinola SM, Fortney KR, Baker B, Janowicz DM, Zwickl B, Katz BP, Blick RJ, Munson RS Jr. Activation of the CpxRA system by deletion of cpxA impairs the ability of Haemophilus ducreyi to infect humans. Infection and Immunity. 2010; 78:3898-904.
8. Wiehe SE, Rosenman MB, Wang J, Katz BP, Fortenberry JD. Chlamydia Screening among young women: Individual- and provider-level differences in testing. Pediatrics. 2011; 127: 336-44.
9. Labandiera-Rey M, Dodd D, Fortney KR, Zwickl B, Katz BP, Janowicz DM, Spinola SM, Hansen EJ. A Haemophilus ducreyi cpxR deletion mutant is virulent in human volunteers. Journal of Infectious Diseases. 2011; 203:1859-65.
10. Tu W, Ghosh P, Katz BP. A stochastic model for assessing Chlamydia trachomatis transmission risk by using longitudinal observational data. J R Statist Soc A. 2011; 174: 975-89.
11. Li W, Katz BP, Spinola SM. Haemophilus ducreyi Lipooligosaccharides Induce Expression of the Immunosuppressive Enzyme Indoleamine 2,3-Dioxygenase via Type 1 Interferons and TNF-α in Human Dendritic Cells. Infection and Immunity. 2011; 79:3338-47.
12. Martinez-Mier EA, Cury JA, Heilman JR, Katz BP, Levy SM, Li Y, Maguire A, Margineda J, O’Mullane D, Phantumvanit P, Soto-Rojas AE, Stookey GK, Villa A, Wefel JS, Whelton H, Whitford GM, Zero DT, Zhang W, Zohouri V. Development of gold standard ion-selective electrode-based methods for fluoride analysis. Caries Research. 2011; 45:3-12.
Older highlighted publications (In chronological order):
1. Katz BP, Hui SL. Variance estimation for medical decision analysis. Stat Med 1989;8:229-41.
2. Katz BP. Estimating transmission probabilities for chlamydial infection. Stat Med 1992;11:565-77.
3. Katz BP, Heck DA, Freund DA, Dittus RS, Paul J, Wright J, Coyte P, Holleman E, Hawker G. Demographic variation in the rate of knee replacement: A multi-year analysis. Health Serv Res 1996:31(2);125-40.
4. Zhou XH, Katz BP, Holleman E, Melfi CA, Dittus R. An empirical Bayes method for studying variation in knee replacement rates. Stat Med 1996;15(17-18):1875-84.
5. Katz BP, Fortenberry JD, Zimet GD, Blythe MJ, Orr DP. Partner-specific relationship characteristics & condom use among young people with sexually transmitted diseases. J Sex Res February 2000;37(1):69-75.
6. Katz BP, Fortenberry JD, Tu W, Harezlak J, Orr DP. Sexual behavior among adolescent women at high risk for sexually transmitted infection. Sexually Trans Dis 2001; 28(5): 247-251.
7. Katz BP and Huntington E. Statistical issues for combining multiple caries diagnostics for demonstrating caries efficacy. J Dent Res2004;83 Special Issue C:C109-12.
8. Katz BP, Holmes AM, Stump TE, Downs SM, Zillich AJ, Ackermann RT, Inui TS. The Indiana chronic disease management program’s impact on Medicaid claims: A longitudinal, statewide evaluation. Medical Care. 2009; 47:154-60.