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Constantin Yiannoutsos

EDUCATION

UNDERGRADUATE:

B.A. in Mathematics concentration in Actuarial Science Central Connecticut State University, New Britain, CT. 1986.

 

 

GRADUATE:

M.S. in StatisticsUniversity of Connecticut, Storrs, CT. 1989

Ph.D. in StatisticsUniversity of Connecticut, Storrs, CT.  1991

 ACADEMIC APPPOINTMENTS 

1994 – 1998:

 

Research Associate. Center for Biostatistics in AIDS Research, Harvard School of Public Health Boston, MA.

 

 

1998 – 2000:

 

Research Scientist Center for Biostatistics in AIDS Research, Harvard School of Public Health Boston, MA.

 

 

2000 – 2002

 

Senior Research Scientist Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, MA.

 

 

2002 – 2008

Associate professor  Indiana University School of Medicine, Department of Medicine, Indianapolis, IN.

 

 

2003 – present

Adjunct associate professor Biostatistics Indiana University Purdue University Indianapolis Department of Mathematical Sciences.

 

 

2008 – present

Professor  Indiana University Department of Medicine, Department of Medicine, Indianapolis, IN.

 

OTHER APPOINTMENTS AND PROFESSIONAL CONSULTANSHIPS

1993 – 1994:             

University Instructor. University of Indianapolis International, Athens, Greece. 

 

 

1995 – 2002

 

University Instructor Harvard University Department of Continuing Education, Cambridge, MA.

2000 – 2002

University lecturer Harvard School of Public Health, Boston, MA. Summer program in Public Health

 

 

1999 – present

Visiting lecturer University of Athens Medical School, Athens, Greece.  Master’s program in Biostatistics

 

 

2006 – 2007

Visiting professor Moi School of Public Health, Eldoret, Kenya

I have been performing analyses of HIV studies, both clinical and observational, for over than 20 years. Currently, I am the co-Director of the East Africa Regional Consortium of the International Epidemiologic Databases to Evaluate AIDS (IeDEA-EA).  My experience with analysis of observational data, and, in particular, developing methods to adjust estimates of mortality and patient retention by incorporating data from patients who have been traced after being lost to program will be crucial for the success of all research proposed by the East Africa IeDEA Regional Consortium and, more generally, the global IeDEA network.  I have also had a strong interest in teaching and mentoring students in Biostatistical and Epidemiological methods and am gratified to see my students, particularly in low and middle-income settings, grow and develop into vibrant, independent scientists.

My current research focus is in the development of Biostatistical methods to support Implementation Science in the HIV treatment “cascade”, which is characterized by significant non-retention of HIV-infected individuals as they move through its successive stages in their disease, particularly in resource-limited settings. Thus, methods which can adjust the inferences from the incomplete group of patients remaining within the cascade are necessary. Our program in East Africa has been a leader in the development of such methods incorporating data from randomly selected patients dropping out of the HIV care cascade to adjust the crude estimates generated from those remaining on observation. With the shifting emphasis from the individual program to the overall system level, implied in the UNAIDS “90-90-90” target, methods which can address the process of disengagement from care from one program and re-engagement in another, are increasingly relevant. 

Recent Publications (In chronological order; selected from over 120 peer reviewed publications):

  1. Harezlak J, Cohen R, Gongvatana A, Taylor M, Buchthal S, Schifitto G, Zhong J, Daar ES, Alger J, Brown M, Singer E, Campbell TB, McMahon D, So YT, Yiannoutsos CT, Navia BA and the HIV Neuroimaging Consortium. Predictors of CNS injury as measured by proton magnetic resonance spectroscopy in the setting of chronic HIV infection and CART. J NeuroVirology, 2014. 20(3):294-303.
  2. Petersen ML, Tran L, Geng E, Deeks SG, Reynolds SJ, Kambugu A, Wood R, Bangsberg D, Yiannoutsos CT, Martin J. Delayed switch of antiretroviral therapy after virologic failure associated with elevated mortality among HIV-infected adults in Africa.AIDS. 2014 ;28(14):2097-107
  3. Yu M, Yiannoutsos CT. Marginal and conditional distribution estimation from double-sampled semi-competing risks data. J Scand Stat. 2014.
  4. Kiragga AN, Lok JJ, Musick BS, Bosch RJ, Mwangi A, Yiannoutsos CT for the East Africa IeDEA Regional Consortium. CD4 trajectory adjusting for dropout among HIV-positive patients receiving combination antiretroviral therapy in an East African HIV care centre. JIAS. Int AIDS Soc. 2014 Aug 14;17
  5. Peterson J, Gisslen M, Zetterberg H, Fuchs D, Shacklett BL, Hagberg L, Yiannoutsos CT, Spudich SS, Price RW. Cerebrospinal Fluid (CSF) neuronal biomarkers across the spectrum 1 of HIV infection: Hierarchy of injury and detection. PLoS ONE. 2014. Dec 26;9(12):e116081. doi: 10.1371/journal.pone.0116081. eCollection 2014.
  6. Anderson AM, Harezlak J, Bharti A, Mi D, Taylor MJ, Daar ES, Schifitto G, Zhong J, Matesan J, Alger JR, Brown M, Singer E, Campbell TB, McMahon DD, Tso Y, Siqueiros L, Paulose S, Gaugh M, Tripoli C, Buchthal S, Gualtieri L, Cohen R, Yiannoutsos C, Letendre SL, Navia BA for the HIV Neuroimaging Consortium. Plasma and cerebrospinal fluid biomarkers are independently predictive of cerebral injury in HIV-Infected individuals on stable combination antiretroviral therapies. J Acquir Immune Defic Syndr; 2015; 69: 29-35.
  7. Duda SN, Farr AM, Lindegren ML, Blevins M, Wester CW, Wools-Kaloustian K, Ekouevi DK, Egger M, Hemingway-Foday J, Cooper DA, Moore RD, McGowan CC, Nash D; International Epidemiologic Databases to Evaluate AIDS (IeDEA) Collaboration. Characteristics and comprehensiveness of adult HIV care and treatment programmes in Asia-Pacific, sub-Saharan Africa and the Americas: results of a site assessment conducted by the International epidemiologic Databases to Evaluate AIDS (IeDEA) Collaboration. J Int AIDS Soc. 2014 Dec 15;17:19045. doi: 10.7448/IAS.17.1.19045. eCollection 2014.
  8. Ballif M, Nhandu V, Wood R, Dusingize JC, Carter EJ, Cortes CP, McGowan CC, Diero L, Graber C, Renner L, Hawerlander D, Kiertiburanakul S, Du QT, Sterling TR, Egger M, Fenner L; International epidemiological Databases to Evaluate AIDS (IeDEA). Detection and management of drug-resistant tuberculosis in HIV-infected patients in lower-income countries. Int J Tuberc Lung Dis. 2014 Nov;18(11):1327-36. doi: 10.5588/ijtld.14.0106.
  9. Huis in ‘t Veld D, Balestre E, Buyze J, Menten J, Jaquet A, Cooper DA, Dabis F, Yiannoutsos CT, Diero L, Mutevedzi P, Fox MP, Messou E, Hoffmann CJ, Prozesky HW, Egger M, Hemingway-Foday JJ, Colebunders R, for the International Epidemiologic Databases to Evaluate AIDS (IeDEA). Determinants of weight evolution among HIV-positive patients initiating antiretroviral treatment in low resource settings. JAIDS. 2015. To appear
  10. Geng EH, Odeny TA, Lyamuya RE, Nakiwogga-Muwanga A, Diero L, Bwana M, Muyindike W, Braitstein P, Somi GR, Kambugu A, Bukusi EA, Wenger M, Wools-Kaloustian KK, Glidden DV, Yiannoutsos CT, Martin J. Estimation of Mortality among HIV-infected people on antiretroviral therapy treatment in east Africa: a sampling based approach in an observational, multisite, cohort study.  Lancet HIV. 2015;2(3):e107-e116.
  11. Geng EH, Neilands TB, Thièbaut R, Bwana MB, Nash D, Moore RD, Wood R, Zannou DM, Althoff KN, Lim PL, Nachega JB, Easterbrook PJ, Kambugu A, Little F, Nakigozi G, Nakanjako D, Kiggundu V, Ki Li PC, Bangsberg DR, Fox MP, Prozesky H, Hunt PW, Davies MA, Reynolds SJ, Egger M, Yiannoutsos CT, Vittinghoff EV, Deeks SG, Martin JN.  CD41 T cell recovery during suppression of HIV replication: an international comparison of the immunological efficacy of antiretroviral therapy in North America, Asia and Africa.  Int J Epidemiol. 2015 Feb;44(1):251-63.
  12. Bakoyannis G, Yiannoutsos CT. Impact of and Correction for Outcome  Misclassification in Cumulative Incidence Estimation. PLoS One. 2015 Sep 2;10(9):e0137454

 

Older highlighted publications (In chronological order):

  1. Hall CD, Dafni U, Simpson D, Clifford D, Wetherill P, Cohen B, McArthur JC, Hollander H, Yiannoutsos CT, Major E,Millar L, Timpone J: Failure of Cytosine Arabinoside Therapy of Human Immunodeficiency Virus-I Associated Progressive Multifocal Leucoencephalopathy. New England Journal of Medicine, 1998; 338:19, 1345-51
  2. Yiannoutsos CT, Major EO, Curfman B, Jensen PN, Gravell M, Hou J, Clifford DB, Hall CD.  Relation of JC virus DNA in the CSF to survival in AIDS patients with biopsy-proven Progressive Multifocal Leukoencephalopathy.  Annals of Neurology, 1999; 45:816-820.
  3. Yiannoutsos CT, De Luca A.  Designs for clinical trials to test the efficacy of therapeutics in progressive multifocal leukoencephalopathy. Journal of Neurovirology, 2001; 7: 369-374 
  4. Nakas C, Yiannoutsos CT, Bosch RJ, Moyssiadis C.  Assessment of diagnostic markers by goodness-of-fit tests. Stat Med; 2003; 22:2503-2513. 
  5. Nakas CT, Yiannoutsos CT.  Ordered multiple class ROC analysis with continuous measurements.  Stat Med 2004; 23:3437-3449
  6. Yiannoutsos CT, Ernst T, Chang L, Lee PL, Richards T, Marra C, Meyerhoff DJ, Jarvic J, Kolson D, Schifitto G, Ellis RJ, Swindells, Simpson DM, Miller EN, Gonzalez RG, Navia BA.  Patterns of regional brain metabolism and diagnostic utility of proton MRS in AIDS Dementia Complex.  Neuroimage 2004; 23: 928:935.
  7. Wruck LM, Yiannoutsos CT, Hughes, MD.   A sequential design to estimate sensitivity and specificity of a diagnostic test. Stat Med, 2006; 25:3458-3473
  8. Yiannoutsos CT, Nakas CT, Navia BA. Assessing multiple-group diagnostic problems with multi-dimensional receiver operating characteristic surfaces: Application to HIV-related neurological injury. Neuroimage, 2008; 40: 248-255.
  9. An M-W, Frangakis CE, Musick BS, Yiannoutsos CT. The need for double-sampling designs in survival studies: An application to monitor PEPFAR. Biometrics, 2009; 65:301-306.
  10. Yiannoutsos CT, An M-W, Frangakis CE, Musick BS, Braitstein P, Wools-Kaloustian K, Ochieng D, Martin JN, Bacon M, Kimaiyo S.  Sampling-Based Approaches to Improve Estimation of Mortality among Patient Dropouts: Experience from a Large PEPFAR-Funded Program in Western Kenya. . PLoS ONE, 2009; 3(12): e3843 doi:10.1371/journal.pone.0003843.
  11. Alonzo TA, Nakas CT, Yiannoutsos CT, Bucher S. A comparison of tests for restricted in the three-class case.  Stat Med 2009; 28:1144-1158.
  12. Yiannoutsos CT. Modeling AIDS survival after initiation of antiretroviral treatment using Weibull models with change points. JIAS, 2009; 12:9
  13. Brinkhof M, Spycher B, Yiannoutsos C, Weigel R, Wood R, Messou E, Boulle A, Sterne J. Adjusting Mortality for Loss to Follow-up: Analysis of five ART programmes in sub-Saharan Africa.  PLoS ONE, 2010; 5(11):e14149.
  14. Yiannoutsos CT, Johnson LF, Boulle A, Musick BS, Gsponer T, Balestre E, Law M, Shepherd BE, Egger M for the International Epidemiologic Databases to Evaluate AIDS (IeDEA) Collaboration. Estimated mortality of adult HIV-infected patients starting treatment with combination antiretroviral therapy. JSTI. 2012; 88 Suppl 2:i33-43.
  15. Yilmaz A, Yiannoutsos CT, Fuchs D, Price RW, Hagberg L, Spudich S, and Gisslén M. Cerebrospinal fluid neopterin decay after initiation of antiretroviral therapy. J Neuroinflammation, 2013; 10:62
  16. Kagaris D, Yiannoutsos CT.  A multi-index ROC-based methodology for high throughput experiments in gene discovery. Int J Data Min Bioinform. 2013; 8:42-65.
  17. An M-W, Frangakis CE, Yiannoutsos CT. Choosing profile double-sampling designs with application to PEPFAR evaluation.  Stat Med, 2014. 
  18. Kiragga AN, Castelnuovo B, Musomba R, Levin J, Kambugu A, Manabe YC, Yiannoutsos CT, Kiwanuka N. Comparison of Methods for Correction of Mortality Estimates for Loss to Follow-Up after ART Initiation: A Case of the Infectious Diseases Institute, UgandaPLoS One. 2013 Dec 31;8(12):e83524.
  19. Poulopoulou S, Karlis D, Yiannoutsos CT, Dafni U. Phase II design with sequential testing of hypotheses within each stage. J Biopharm Stat, 2014. 24:768-84

Department of Biostatistics | 410 W. Tenth St., Suite 3000 | Indianapolis, IN 46202 | Ph: (317) 274-2661 | Fax: (317) 274-2678