Zhangsheng Yu

Contact Information:

410 W 10th Street (Health Information and Translational Science Buliding)

Room 3021

Indianapolis, IN 46202

Office: (317) 274-2688

Email: yuz(at)



University of Michigan, Ph.D. (Biostatistics)                                                                       2006

Bowling Green State University, M. A. (Mathematics with specialization in Statistics)                2002

East China Normal University, B. Sc.(Mathematical statistics)                                               1996


Associate Professor

Department of Biostatistics, Indiana University School of Medicine, Indianapolis, IN       2014-present

Assistant Professor

Department of Biostatistics, Indiana University School of Medicine, Indianapolis, IN       2008-2014

Assistant Professor

Division of Biostatistics, Ohio State University College of Public Health, Columbus, OH   2006-2008

Visiting Scientist

Department of Biostatistics, Harvard School of Public Health, Boston, MA                      2005-2006

Research Assistant

Department of Biostatistics, University of Michigan, Ann Arbor, MI                                2002-2006

Teaching Assistant 

Department of Mathematics, Bowling Green State University, Bowling Green, OH            2000-2002


President         Central Indiana Chapter of American Statistical Association              2011-2012

Vice president  Central Indiana Chapter of American Statistical Association               2010-2011

Member           American Statistical Association                                                     2004-present

Methodology Research

Survival data analysis, longitudinal data analysis, nonparametric regression using spline and local kernel method, variable selection.


Collaborative Research

Pediatric pulmonology, cancer, hypertension, health service research, nephrology, pain.

Methodology publications

1. Yu, Z. & Lin, X. (2008) Nonparametric Regression Using Kernel Estimating Equations for Correlated Failure Time Data Analysis. Biometrika, 95, 123-137. 

2. LIU, L. & YU, Z. (2008). A Likelihood Reformulation Method in Mixed Models with Non-normal Random Effect. Statistics in Medicine. 27:3105–3124.

3. Yu, Z. & Lin, X. (2009) Semiparametric Regression with time-dependent regression coefficients for failure time data analaysis. Statistica Sinica20, 853-869.

4. Yu, Z, Tu, W., and Lee, M-L. (2009). A Semiparametric Threshold Regression Analysis of Sexually Transmitted Infections in Adolescent Women. Statistics in Medicine, 28, 3029-3042.

5. Wilding, GE, Cai, XY, Hudson, A, Yu, Z (2010). A Linear Model Based Test for the Heterogeneity of Conditional Correlations. Journal of Applied Statistics10, 2355-66.

6. YU, Z, Liu, L. (2011). A Joint Model of Recurrent Events and a Terminal Events with Nonparametric Covariate Function. Statistics in Medicine30 (22), 2683 – 95.

7. Yu, Z, Lin, X., Tu, W. (2011) Semiparametric Frailty Models for Cluster Failure Time Data. Biometrics, 68 (2), 429-36.

8. Yu, Z, Liu , Bravata, DM, Williams, LS, Tepper, RS. (2012) A semiparametric recurrent events model with time-varying coefficients, Statistics in Medicine, DOI: 10.1002/sim.5575.

Collaborative publications

1. RUO, K. & YU, Z. (2000). The Pressure of Attracting Talent in China and Relevant Thoughts. Northwestern Population(in Chinese).

2. YU, Z. & HUANG, C. (2001) Projections of Capacity and Structure of Labor Employment in Shanghai in the Period of the “Tenth Five Year Plan”. Population Journal (in Chinese), 1, 25-28.

3. Moe S, Saifullah A, LaClair R, Usman S, and Yu Z (2009) Randomized trial of cholecalciferol versus  doxercalciferol for lowering PTH in CKD. Clinical Journal of the American Society of Nephrology 5, 299-306.

4. Noureddine,  L, Usman, SA, Yu, Z, Moe, SM (2010) Heptitis C Increases the Risk of Progression of CKD and Death in Patients with Glomerulonephritis. American Journal of Nephrology 32, 311-316

5. Pelletier RP, Hadley G, Adams P, Henry ML, Yu Z,  Ferguson, RM (2009). Even a single, remontely positive post-transplant alloantibody test correlates with increased chronic allograft nephropathy and graft loss after kidney transplantation. Ibnosina Journal of Medicine and Biomedical Sciences. 1, 7-15.

6. Balinotti JE, Chakr VC, Tiller C, Kimmel R, Coates C, Kisling J, Yu Z., Nguyen J, and R.S. Tepper MD. Growth of lung parenchyma in infants and toddlers with chronic lung disease of infancy. (2009) American Journal of Respiratory and Critical Care Medicine, 181, 1093-1097.

7. Friedman, NA, Yu, Z, Jular, BE, Nguyen, JT, Strother, M, Quinney, SK, Li, L, Inman, M, Gomez, G, Shihabi, Z, Moe, S. (2010) Independent Influence of Dietary Protein and Weight on Markers of Kidney Function and Disease in Obese Individuals. Kidney International 78, 693-97.

8. Yao, W, Barbe-Tuana, FM, Llapur, CJ, Jones, MH, Tiller, C, Kimmel, R, Kisling, J, Nguyen, ET, Nguyen, JT, Yu, Z,Kaplan, MH, Tepper, RS. (2010) Evaluation of Airway Reactivity and Immune Characteristics as Risk Factors for Wheezing Early in Life. The Journal of Allergy and Clinical Immunology126, 483-488.

9. Rao L, Tiller C., Coates C., Kimmel R., Applegate K, Grannoth-Cook J., Denski C., Nguyen J, YU Z., Hoffman R., Tepper S. (2010) Lung Growth in Infants and Toddlers Assessed by Multi-slice Computed Tomography. Academic Radiology, 17, 1128-35.

10. Williams, LS, Ofner, S., Yu, Z., Beyth, R., Plue, L, Damush, T. (201`) Automated Screening and Treatment Reminders Can Improve Detection and Management of Post-stroke Depression. Journal of General Internal Medicine,26(8), 852-7

11. Sayar, H,… Yu, Z, …, Cripe, L. (2011) Thrice weekly azacitidine for two weeks with erythropoietin does not improve hematological responses in patients with anemia and lower-risk myelodysplastic syndrome: a study of the Hoosier Oncology Group. Leukemia Research, 35 (8): 1108-10.

12. YU, Z, Liu, L. (2011). A Joint Model of Recurrent Events and a Terminal Events with Nonparametric Covariate Function. Statistics in Medicine30 (22), 2683 – 95.

13. Damush, T., Ofner, S., Yu, Z., Plue, L., Beyth, R., Williams LS. Stroke Self-Management: A Randomized Controlled Pilot Study of Veterans with Stroke. Translational Behavior Sciences1(4), 561-572.

14. Tu, W, Eckert, GJ, Jung, J, DiMeglio, L, Yu, Z, Pratt, H. (2011) Intensified Effect of Adiposity on Blood Pressure in Overweight and Obese Children. Hypertension, 58(5), 818-24.

15. Sarria, E., Mattiello, PT, Rao, L., Tiller, C., Kimmel, R., Poindexter, B, Applegate, KE, Granroth-Cook, J., Denski, C., Nguyen, J., YU, Z., Hoffman, E., Tepper, RS. (2012) Quantitative Assessement of Chronic Lung Disease of Infancy using Computed Tomography. European Respiratory Journal39(4) 992-9

16. Kim, YJ, Hall, GL, Christoph K., Tabbey, R., Yu, Z, Tepper, RS, and Eigen, H. (2011) Pulmonary Diffusing Capacity in Healthy Caucasian Children. European Respiratory Journal47(5), 469-75.

17. Singh N, Sun Q, Nadasdy T, Adams P, DiPaola NR, Pesavento T, Winters H, Satoskar A, Yu Z, Henry M, Hadley GA, Pelletier RP. (2012) The pathogenesis of acute allograft dysfunction in desensitized renal transplant recipients. Clinical Transplant, DOI: 10.1111/j.1399-0012.2012.01684.x

18. Khalil J. Diab, Zhangsheng Yu,Karen L. Wood, James A. Shmalo,Francis D. Sheski, Mark O. Farber, David S. Wilkes, Robert P. Nelson Jr. (2012) Comparison of Pulmonary Complications after Nonmyeloablative and Conventional Allogeneic Hematopoietic Cell Transplant. Biol Blood Marrow Transplant,

Department of Biostatistics | 410 W. Tenth St., Suite 3000 | Indianapolis, IN 46202 | Ph: (317) 274-2661 | Fax: (317) 274-2678