Yong Zang


Department of Biostatistics
Indiana University School of Medicine
410 West 10th Street, Suite 5000
Indianapolis, IN 46202
Email: zangy[at]
Office: 317-278-2108

MD Anderson Cancer Center, Postdoctoral fellow (Biostatistics), 2011-2014
The University of Hong Kong, Ph.D. (Statistics), 2007-2011
University of Science and Technology of China, M.S. (Statistics), 2004-2007
Anhui University, B.S. (Statistics), 2000-2004 


2014-2016 Assistant Professor, Department of Mathematical Sciences, Florida Atlantic University
2016- Assistant Professor, Department of Biostatistics, Indiana University School of Medicine

Clinical Trial Design; Population Genetics

Selected Publications: 


1. Zang Y, Zhang H, Yang YN and Zheng G. ``Robust genomic control and robust delta-centralization for case-control association studies'' Human Heredity, 63: 187-195, 2007.

2. Zang Y, Fung WK and Zheng G. ``Tail strength to combine two p-values: Their correlation cannot be ignored'' American Journal of Human Genetics, 84: 291-295, 2009.

3. Zang Y,  Fung WK and Zheng G. ``Asymptotic powers for matched trend tests and robust matched trend test in case-control genetic association studies'' Computational Statistics and Data Analysis, 54: 65-77, 2010.

4. Zang Y, Fung WK and Zheng G. ``Simple algorithms to calculate asymptotic null distributions for robust tests in case-control genetic association studies in R'' Journal of Statistical Software, 33(8), 2010.

5. Zang Y and Fung WK. ``Robust tests for matched case-control genetic association studies'' BMC Genetics 11(91), 2010.

6. Zang Y and Fung WK. ``Robust Mantel-Haenszel test under genetic model uncertainty allowing for covariates in case-control association studies'' Genetic Epidemiology 35: 695-705, 2011.

7. Zang Y and Yuan Y. ``A shrinkage method for testing the Hardy-Weinberg equilibrium in case-control studies'' Genetic Epidemiology 37: 743-750, 2013.

8. Zang Y, Lee JJ and Yuan Y. ``Adaptive designs for identifying optimal biological dose for molecularly targeted agents'' Clinical Trials 11: 319-327, 2014.

9. Zang Y and Lee JJ. ``Adaptive clinical trial designs in oncology'' Chinese Clinical Oncology 3(4), 2014. 

10.Zang Y, Liu S and Yuan Y.``Optimal marker-adaptive designs for targeted therapy based on imperfectly measured biomarkers'' Journal of the Royal Statistical Society: Series C 64: 635-650, 2015.

11.Guo B, Zang Y and Yuan Y. ``A Bayesian phase I/II clinical trial design in the presence of informative dropouts.'' Statistics and Its Interface 8: 217-226, 2015.

12.Zang Y and Guo  B. ``Optimal two-stage enrichment design correcting for biomarker misclassification.'' Statistical Methods in Medical Research in press.

13.Zang Y, Lee JJ and Yuan Y. `Two-stage marker stratified clinical trial design in the presence of biomarker misclassification.'' Journal of the Royal Statistical Society: Series C 65: 585-601, 2016.

14.Zang Y, Liu S and Yuan Y. ``Optimal marker-strategy clinical trial design to detect predictive markers for targeted therapy.'' Biostatistics 17: 549-560, 2016.

15.Zang Y and Guo B. ``Two-stage methods to implement and analyze the biomarker-guided clinical trail designs in the presence of biomarker misclassification.'' Precision Medicine 2: e1230, 2016.

16.Zang Y and Lee JJ. ``A robust two-stage design identifying the  optimal biological dose for phase I/II clinical trials.'' Statistics in Medicine 36: 27-42, 2017.

17. Zang Y and Yuan Y. ``Optimal sequential enrichment design for phase II clinical trials." Statistics in Medicine 36: 54-66, 2017.

Department of Biostatistics | 410 W. Tenth St., Suite 3000 | Indianapolis, IN 46202 | Ph: (317) 274-2661 | Fax: (317) 274-2678