Ziyue Liu



M.A.&M.M. Medicine (M.D. equivalent) Sun Yat-sen University 1997
M.S. Biomathematics North Carolina State University 2004
Ph.D. Biostatistics University of Pennsylvania 2010


Academic Appointment

Assistant Professor

of Biostatistics

Indiana University School of Public Health

and School of Medicine


Associate Professor

of Biostatistics

Indiana University School of Public Health

and School of Medicine







Methodological Research Interests

Smoothing splines, functional data analysis, state space method, time series analysis, mixed effects models, and application driven methods.

Collaborative Research Interests

Generally speaking I am interested in all kinds of biomedical research. Here are some example areas in which I have worked or am working: bone, cancer clinical trials, HIV, shockwave lithotripsy, menopause, cardiac arrest, chronic renal insufficiency, SLE, STIs, and hypertension.

Methodological Papers

  1. Liu Z, Guo W. Modeling diurnal hormone profiles by hierarchical state space models. Statistics in Medicine, Accepted.
  2. Liu Z. A particle filter approach to multiprocess dynamic models with application to hormone data. Statistics in Biosciences, Accepted.
  3. Shen C, Yu Z, Liu Z. The use of statistics in heart rhythm research: a review. Heart Rhythm, 2015, 12:1376-1386.
  4. Liu Z, Cappola AR, Crofford LJ, Guo W. Modeling bivariate longitudinal hormone profiles by hierarchical state space models. Journal of American Statistical Association, 2014, 109:108-118.
  5. Liu Z, Yu M, Tong Y. Testing and sample size for polygonal one-sided hypotheses on bivariate binary outcomes. Statistics in Biopharmaceutical Research, 2013, 5:1-17.
  6. Liu Z, Guo W. Functional mixed effects models. WIREs Computational Statistics, 2012, 4:527-534.
  7. Liu Z, Guo W. fmixed: A SAS Macro for Smoothing-Spline-Based Functional Mixed Effects Models. Journal of Statistical Software, Code Snippet, 2011, 43:1–13.
  8. Liu Z, Guo W. Data Driven Adaptive Spline Smoothing. Statistica Sinica, 2010, 20:1143–1163.


Collaborative Papers

    1. Handa, RK, Johnson CD, Connors BA, Evan AP, Lingeman JE, Liu Z. Percutaneous renal access: surgical factors involved in the acute reduction of renal function. Journal of Endourology, Accepted.
    2. Dunmire B, Harper JD, Cunitz BW, Lee FC, His R, Liu Z, Bailey MR, Sorensen MD. Use of the acoustic shadow width to determine kidney stone size with ultrasound. The Journal of Urology, Accepted. PMID:26301788
    3. Hahn NM, Knudsen BS, Daneshmand S, Kock MO, Bihrle R, Foster RS, Garden TA, Cheng L, Liu Z, Breen T, Fleming MT, Lance R, Ryan CM, Corless CL, Alva AS, Mitchell G, Shen SS, Huang F, Gertych A, Gallick GE, Mallick J, Ryan C, Galsky MD, Lerner SP, Posadas EM, Sonpavde G. Neoadjuvant dasatinib for muscle-invasive bladder cancer with tissue analysis of biologic activity. Urologic Oncology: Seminars and Original Investigations, Accepted.
    4. Pradhan K, Mund J, Case J, Gupta S, Liu Z, Gathirua-Mwangi W, McDaniel A, Renbarger J, Champion V. Difference in circulating endothelial progenitor cells among childhood cancer survivors treated with and without radiation. Journal of Hematology & Thrombosis, Accepted.
    5. Liu Z, Weaver J, de Papp A, Li Z, Martin J, Allen K, Hui S, Imel EA. Disparities in osteoporosis treatments. Osteoporosis International, Accepted. PMID:26216226
    6. Lee F, Hsi R, Sorensen M, Paun M, Dunmire B, Liu Z, Bailey M, Harper H. Renal vasoconstriction occurs early during SWL using a renal protection protocol in humans. Journal of Endourology, Accepted.  PMID:26239232
    7. Gupta S, Slaven J, Kamendulis J, Liu Z. A randomized, controlled trial of the effect of Rilpivirine versus Efavirenz on cardiovascular risk in healthy volunteers. Journal of Antimicrobial Chemotherapy, Accepted. PMID:26169561
    8. Reger MK, Zollinger TW, Liu Z, Jones J, Zhang J. Urinary phytoestrogens and cancer, cardiovascular, and all-cause mortality in the continuous National Health and Nutrition Examination Survey. European Journal of Nutrition, Accepted. PMID:25943648
    9. Pradhan K, Mund J, Claussen H, Gosiengfiao Y, Radulescu V, Ballard J, Liu Z, Vik T, Case J. A pilot study of circulating endotheliao and hematopoietic progenitor cells in children with sarcomas. Journal of Pediatric Hematology and Oncology, 2015, 37:443-448. PMID:26115508, PMCID:PMC4506214
    10. Shinha T, Mi D, Liu Z, Orschell CM, Lederman MM, Gupta SK. Relationships between renal parameters and serum and urine markers of inflammation in those with and without HIV infection. AIDS Research and Human Retroviruses, 2015, 31:375-383. PMID:25646974, PMCID:PMC4378711
    11.  Hays T, Mund JA, Liu Z, Case J, Ingram DA, Gupta SK. Endothelial colony forming cells and inflammatory monocytes in HIV. JAIDS, 2015, 68:550-553. PMID:25564108, PMCID:PMC4357537
    12. Handa RK, Johnson CD, Connors BA, Evan AP, Phillips CL, Liu Z. Shock wave lithotripsy does not impair renal function in a swine model of metabolic syndrome. Journal of Endourology, 2015, 29:468-473. PMID:25285417, PMCID:PMC4394175
    13. Handa RK, Liu Z, Connors BA, Alloosh M, Baile DP, Tune JD, Sturek M, Evan AP, Lingeman JE. Effect of renal shock wave lithotripsy on the development of metabolic syndrome in a juvenile swine model: a pilot study. The Journal of Urology, 2015, 193:1409-1416. PMID:25245490, PMCID:PMC4369464
    14. Burr DB, Liu Z, Allen MR. Duration-dependent effects of clinically relevant oral alendronate doses on cortical bone toughness in beagle dogs. Bone, 2015, 71:58-62. PMID:25445446, PMCID:PMC4274196
    15. Handa RK, Evan AP, Connors BA, Johnson CD, Liu Z, Alloosh M, Sturek M, Evans-Molina C, Mandeville JA, Gnessin E, Lingerman JE. Shock wave lithotripsy targeting of the kidney and pancreas does not increase the severity of metabolic syndrome in a porcine model. The Journal of Urology, 2014, 192:1257-1265. PMID:24657667, PMCID:PMC4168006
    16. Goodwin CB, Li XJ, Mali R, Chan G, Kang MW, Liu Z, Vanhaesebroeck B, Neel BG, Loh ML, Lannutti BJ, Kapur R, Chan RJ. PI3K p110 uniquely promotes gain-of-function Shp2-induced GM-CSF hypersensitivity in a model of JMML. Blood, 2014, 123:2838-2842. PMID:24553178, PMCID:PMC4007610
    17. W­ang J, Li Z, He Y, Pan F, Chen S, Rhodes R, Nguyen L, Yuan J, Jiang L, Yang X, Weeks O, Liu Z, Zhou J, Ni H, Cai C, Xu M, Yang F-C. Loss of Asxl1 leads to myelodysplastic syndrome-like disease in mice. Blood, 2014 123:541-553. PMID:24255920, PMCID:PMC3901067
    18. Wang YN, Simon JC, Cunitz BW, Starr FL, Paun M, Liggitt DH, Evan AP, McAteer J, Williams J, Liu Z, Barbrina D, Bailey MR. Focused ultrasound to displace renal calculi: threshold for tissue injury. Journal of Therapeutic Ultrasound, 2014, 2:5. PMID:24921046, PMCID:PMC4036593
    19. Wang T, Green LA, Gupta SK, Kim C, Wang L, Almodovar S, Flores SC, Prudovsky IA, Jolicoeur P, Liu Z, Clauss M. Transfer of Intracellular HIV Nef to Endothelium Causes Endothelial Dysfunction. PLOS ONE, 2014, 9(3) e91063. PMID:24608713, PMCID:PMC3946685
    20. Gupta SK, Mi D, Moe SM, Dube MP, Liu Z. Effects of switching from Efavirenz to Raltegravir on endothelial function, bone mineral metabolism, inflammation, and renal function: a randomized, controlled trial. JAIDS, 2013, 64:279-283. PMID:24278992, PMCID:PMC4091630
    21. Gupta SK, Mi D, Dube MP, Saha CK, Johnson RM, Stein JM, Clauss MA, Mather KJ, Desta Z, Liu Z. Pentoxifylline, inflammation, and endothelial function in HIV-infected patients: a randomized, placebo-controlled trial. PLOS ONE, 2013, 8:e60852. PMID:23593327, PMCID:PMC3621886
    22. Cai H, Chiorean EG, Chiorean MV, Rex DK, Robb BW, Hahn NM, Liu Z, Loehrer PJ, Harrison ML, Xu Y. Elevated phospholipase A2 activities in plasma samples from multiple cancers. PLOS ONE, 2013, 8:e57081. PMID:23451150, PMCID:PMC3579817
    23. Nabinger SC, Li XJ, Ramdas B, He Y, Zhang X, Richine B, Bowling JD, Fukuda S, Goenka S, Liu Z, Feng GS, Yu M, Sandusky GE, Boswell HS, Zhang ZY, Kapur R, Chan RJ. The protein tyrosine phosphatase, Sph2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo. Leukemia, 2013, 27:398-408. PMCID: PMC3916934
    24. Handa RK, McAteer JA, Connors BA, Liu Z, Evan AP, Lingeman JE. Optimizing an escalating shock wave amplitude treatment strategy to protect the kidney from injury during shock wave lithotripsy. British Journal of Urology International, 2012, 110:e1041. PMCID: PMC3749741
    25. Li G, Williams JC, Pishchalnikov YA, Liu Z, McAteer JA. Size and location of defects at the coupling interface affect lithotripter performance. British Journal of Urology International, 2012, 110:e887. PMID:22938566, PMCID:PMC3498589
    26. Seng S, Liu Z, Chiu SK, Proverbs-Singh T, Sonpavde G, Choueiri TK, Tsao CK, Yu M, Hahn NM, Oh WK, Galsky MD. Risk of venous thromboembolism in cancer patients treated with cisplatin: A systematic review and meta-analysis. Journal of Clinical Oncology, 2012, 30:4416-4426. PMID: 23150697
    27. Proverbs-Singh T, Chiu SK, Liu Z, Seng S, Sonpavde G, Choueiri TK, Tsao CK, Yu M, Hahn NM, Oh WK, Galsky MD. Arterial thromboembolism in cancer patients treated with cisplatin: A systemic review and meta-analysis. Journal of the National Cancer Institute, 2012, 104:1837-40. PMID: 23093559
    28. Sivendran S, Liu Z, Portas LJ, Yu M, Hahn N, Sonpavde G, Oh WK, Galsky MD. Treatment-related mortality with vascular endothelial growth factor receptor tyrosine kinase inhibitor therapy in patients with advanced solid tumors: a meta-analysis. Cancer Treatment Reviews, 2012, 38:919-925. PMID:22651902,
    29. Su HI, Chen YC, Hwang WT, Liu Z, Su TP, Chen TJ, Barnhart KT, Yang YX. Risk and benefits of menopausal hormone therapy in postmenopausal Chinese Women. Menopause: The Journal of the North American Menopause Society, 2012, 19:931-941. PMID:22453198, PMCID: PMC3387327
    30. Schmitt JM, Sommers SR, Fisher W, Ansari R, Robin E, Koneru K, McClean J, Liu Z, Tong Y, Hanna N. Sunitinib plus paclitaxel in patients with advanced esophageal cancer: a phase II study from the Hoosier Oncology Group. Journal of Thoracic Oncology, 2012, 7:760–763. PMID:22425927
    31. Gabler NB, French B, Strom BL, Liu Z, Palevsky HI, Taichman DB, Kawut SM, Halpern SD. Race and sex differences in response to endothelin receptor antagonists for pulmonary arterial hypertension. Chest, 2012, 141:20–26. PMID:21940766
    32. Che D, Li L, Kopil C, Liu Z, Guo W, Neumar RW. Impact of therapeutic hypothermia onset and duration on survival, neurologic function, and neurodegeneration after cardiac arrest. Critical Care Medicine, 2011, 39:1423–1430. PMID:21610611, PMCID: PMC3102228  
    33. Gupta SK, Mi D, Liu Z, Saha C. Endothelial, Inflammatory, Coagulation, Metabolic Effects and Safety of Etravirine in HIV-Uninfected Volunteers. AIDS Patient Care and STDs, 2011 25:327–331. PMID:21470045, PMCID: PMC3143389
    34. Freeman EW, Sammel MD, Lin H, Liu Z, Gracia CR. Duration of menopause hot flashes and associated risk factors. Obstetrics & Gynecology, 2011, 117:1095–1104. PMID:21508748, PMCID:PMC3085137
    35. Sammel MD, Freeman EW, Liu Z, Lin H, Guo W. Factors that influence entry into stages of the menopausal transition. Menopause: The Journal of the North American Menopause Society, 2009, 16:1218–1227. PMID:19512950, PMCID: PMC2783664

      G651, Biostatistics I, Spring 2011

      PBHL-G652, Biostatistics II, Fall 2012

      PBHL-B663, Applied Survival for MPH, Spring 2013, Spring2014, Fall 2014

      PBHL-B571, Linear Models, Fall 2015, 2016

      PBHL-B581, Biostatistical Computing (Introduction to SAS), Fall 2015, 2016

      Department of Biostatistics | 410 W. Tenth St., Suite 3000 | Indianapolis, IN 46202 | Ph: (317) 274-2661 | Fax: (317) 274-2678